Case Studies in Protein Structure Prediction with Real-valued Genetic Algorithms
نویسندگان
چکیده
Accurate and reliable protein structure prediction PSP eludes researchers primar ily because the search for the minimum energy conformer is computationally intractable This research discusses the application of several distinct genetic algorithms GAs as optimum seeking techniques for PSP problems The e ectiveness and e ciency of each algorithm is studied empirically The speci c algorithmic designs studied are a farm ing model parallel hybrid simple GA a REal valued Genetic Algorithm with Limited Constraints REGAL incorporating domain knowledge and a island model parallel REGAL with a novel migration operator Para REGAL
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